编者按：第65届美国心脏病学学会（ACC）科学年会将于2016年4月2~4日在芝加哥隆重举行。今日，ACC官网揭示，本届年会有5场最新临床试验专题（Late-Breaking Clinical Trial Sessions）和2场特色临床研究专题（Clinical Research Sessions）将呈现最新科学进展。另外，还有2场LBCT深入挖掘专题（Deep Dive Sessions）。现编译于此，与广大读者提前共享。

　　ACC.16开幕式和ACC/JACC联合最新临床试验

　　专题：401

　　时间：星期六，4月2日，8:00~10:00

　　地点：ACC.16 Main Tent (North Hall B1)

　　★　Partner 2: Transcatheter Aortic Valve Replacement Compared with Surgery in Intermediate Risk Patients with Aortic Stenosis: Final Results from the Randomized Placement of Aortic Transcatheter Valves 2 Study

　　●　Partner 2试验最终结果：在主动脉狭窄中危患者中比较经导管主动脉瓣置换与手术治疗

　　★　HOPE 3: Blood Pressure Lowering in People at Moderate Risk

　　●　HOPE 3：中危人群的降压治疗

　　★　HOPE 3: Effects of Combined Lipid and BP-Lowering on Cardiovascular Disease in a Moderate Risk Global Primary Prevention Population

　　●　HOPE 3：联合降脂和降压治疗对全球一级预防中危人群心血管疾病的作用

　　ACC/JAMA联合最新临床试验

　　专题：404

　　时间：星期日，4月3日，8:00~9:15

　　地点：ACC.16 Main Tent (North Hall B1)

　　★　ACCELERATE: Impact of the Cholesteryl Ester Transfer Protein Inhibitor Evacetrapib on Cardiovascular Events: Results of the ACCELERATE trial

　　●　ACCELERATE：胆固醇酯转运蛋白抑制剂Evacetrapib对心血管事件的影响

　　★　GAUSS-3: Comparison of PCSK9 Inhibitor Evolocumab Versus Ezetimibe in Statin-intolerant Patients: The Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin Intolerant Subjects 3 (GAUSS-3) Trial

　　●　GAUSS-3：在他汀不耐受患者中比较PCSK9抑制剂Evolocumab与依折麦布的使用

　　★　FH Mutations: Low-density Lipoprotein Cholesterol， Familial Hypercholesterolemia Mutation Status and Risk for Coronary Artery Disease

　　●　FH突变：低密度脂蛋白胆固醇、家族性高胆固醇血症突变状态和冠状动脉疾病风险

　　★　Stepathlon: Reproducible Impact of a Global Mobile Health (mHealth) Mass-Participation Physical Activity Intervention on Step Count， Sitting Behavior and Weight: the Stepathlon Cardiovascular Health Study

　　●　Stepathlon心血管健康研究：全球移动健康（mHealth）大众参与体力活动干预对步数、久坐行为和体重的可重复影响

　　★　Low Risk Chest Pain: Involving Patients with Low Risk Chest Pain in Discharge Decisions: A Multicenter Trial

　　●　低危胸痛：低危胸痛患者参与出院决策的一项多中心试验

　　ACC/TCT联合最新临床试验

　　专题：405

　　时间：星期日，4月3日，10:45~12:00

　　地点：ACC.16 Main Tent (North Hall B1)

　　★　DANish (DEFERred stent): The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: DEFERred stent implantation in connection with primary PCI

　　●　DANish（DEFERred支架）：ST段抬高心肌梗死患者优化急性期治疗的第3项丹麦研究：直接PCI相关的DEFERred支架置入

　　★　DANish (iPOST conditioning): The Third DANish Study of Optimal Acute Treatment of Patients with ST-segment Elevation Myocardial Infarction: iPOSTconditioning during primary PCI

　　●　DANish（iPOST处置）：ST段抬高心肌梗死患者优化急性期治疗的第3项丹麦研究：直接PCI期间缺血后适应（iPOST）处置

　　★　Early-BAMI: Effect Of Early Administration Of Intravenous Beta Blockers In Patients With ST-elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention. The Early-BAMI trial

　　●　Early-BAMI：ST段抬高心肌梗死患者直接PCI前早期静脉使用β受体阻滞剂的作用

　　★　Sapien 3: Sapien 3 Transcatheter Aortic Valve Replacement versus Surgery in Intermediate-Risk Patients with Severe Aortic Stenosis: A Propensity-Matched Comparison of One-Year Outcomes

　　●　Sapien 3：重度主动脉狭窄中危患者行Sapien 3经导管主动脉瓣置换与手术治疗1年预后的一项倾向匹配比较分析

　　★　TAVR Volume/Outcome: Relationship Between Procedure Volume and Outcome for Transcatheter Aortic Valve Replacement in U.S. Clinical Practice: Insights from the STS/ACC TVT Registry

　　●　STS/ACC TVT注册研究中TAVR数量/预后：美国临床实践中经导管主动脉瓣置换数量和预后的关系

　　ACC/NEJM联合最新临床试验

　　专题：410

　　时间：星期一，4月4日，8:00~9:15

　　地点：ACC.16 Main Tent (North Hall B1)

　　★　Resuscitation Outcomes: Antiarrhythmic Drugs for Shock-Refractory Out-of-Hospital Cardiac Arrest: The Resuscitation Outcomes Consortium Amiodarone， Lidocaine or Placebo Study

　　●　复苏预后：抗心律失常药物用于顽固性休克院外心搏骤停：联合胺碘酮、利多卡因或安慰剂复苏预后研究

　　★　FIRE AND ICE: Largest Randomized Trial Demonstrates an Effective Ablation of Atrial Fibrillation: the FIRE AND ICE Trial

　　●　火与冰试验：显示房颤有效消融的最大规模随机试验

　　★　Rate v Rhythm: A Randomized Trial of Rate Control Versus Rhythm Control for Atrial Fibrillation after Cardiac Surgery

　　●　心率与心律：心脏手术后比较房颤心率控制与心律控制的随机试验

　　★　LATITUDE-TIMI 60: The Losmapimod To Inhibit P38 MAP Kinase As A Therapeutic Target And Modify Outcomes After An Acute Coronary Syndrome (LATITUDE-TIMI 60) Trial: Primary Results Of Part A

　　●　LATITUDE-TIMI 60试验A部分主要结果：抑制P38 MAPK作为Losmapimod用于急性冠状动脉综合征治疗靶点

　　★　CARIN: CMX-2043 for Prevention of Contrast Induced Acute Kidney Injury: The Primary Results of the CARIN Trial

　　●　CARIN试验主要结果：CMX-2043用于预防造影剂诱导的急性肾损伤

　　最新临床试验

　　专题：412

　　时间：星期一，4月4日，10:45~12:00

　　地点：ACC.16 Main Tent (North Hall B1)

　　★　ATMOSPHERE: Direct Renin-inhibition With Aliskiren Alone And In Combination With Enalapril， Compared With Enalapril， In Heart Failure (the ATMOSPHERE Trial)

　　●　ATMOSPHERE：在心衰患者中比较直接肾素抑制剂阿利吉仑与依那普利单药治疗与联合治疗

　　★　TRUE-AHF: Effect of Ularitide on Short- and Long-Term Clinical Course of Patients with Acutely Decompensated Heart Failure: Primary Results of the TRUE-AHF Trial

　　●　TRUE-AHF试验主要结果：乌拉立肽对急性失代偿性心衰患者短期和长期临床病程的影响

　　★　IxCell-DCM: The Final Results of the IxCell-DCM Trial: Transendocardial Injection of Ixmyelocel-T in Patients with Ischemic Dilated Cardiomyopathy

　　●　IxCell-DCM试验最终结果：缺血性扩张型心肌病患者心内膜注射Ixmyelocel-T

　　★　INOVATE-HF: The Effect of Vagal Nerve Stimulation in Heart Failure: Primary Results of the INcrease Of VAgal TonE in chronic Heart Failure (INOVATE-HF) Trial

　　●　INOVATE-HF主要结果：迷走神经刺激术对心衰的影响

　　★　IMPEDANCE-HF: Non-invasive Lung IMPEDANCE-Guided Preemptive Treatment in Chronic Heart Failure Patients: a Randomized Controlled Trial (IMPEDANCE-HF trial)

　　●　IMPEDANCE-HF：慢性心衰患者采用非侵入性肺IMPEDANCE指导的优先治疗

　　特色临床研究专题

　　专题Ⅰ：406

　　时间：星期日，4月3日，12:30~13:45

　　地点：Room S103cd

　　★　MR: Papillary Muscle Approximation versus Undersizing Restrictive Annuloplasty Alone for Severe Ischemic Mitral Regurgitation: a Randomized Clinical Trial

　　●　MR：比较乳头肌近似值与限制性瓣环成形术下限在重度缺血性二尖瓣反流中应用的随机临床试验

　　★　Isch MR: Two-year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation: A Randomized Clinical Trial from The Cardiothoracic Surgical Trials Network

　　●　Isch MR：中度缺血性二尖瓣反流行手术治疗的2年预后：心胸外科手术试验网络的一项临床试验

　　★　Surgery Ischemic HF: Ten-Year Outcome of Coronary Artery Bypass Graft Surgery Versus Medical Therapy in Patients with Ischemic Cardiomyopathy: Results of the Surgical Treatment for Ischemic Heart Failure Extension Study

　　●　缺血性心衰延长研究手术治疗结果：比较缺血性心肌病患者行冠状动脉旁路移植术与药物治疗的10年预后

　　★　CoreValve: 3-Year Results From the CoreValve US Pivotal High Risk Randomized Trial Comparing Self-Expanding Transcatheter and Surgical Aortic Valves

　　●　CoreValve试验3年结果：比较自膨式经导管瓣膜与外科主动脉瓣膜

　　★　Valve Deterioration: Incidence and Outcomes of Valve Hemodynamic Deterioration in Transcatheter Aortic Valve Replacement in U.S. Clinical Practice: A Report from the Society of Thoracic Surgery / American College of Cardiology Transcatheter Valve Therapy Registry

　　●　STS/ACC经导管心脏瓣膜治疗注册研究报告：美国临床实践中经导管主动脉瓣置换患者瓣膜血液动力学恶化的发生率和预后

　　专题Ⅱ：416

　　时间：星期一，4月4日，14:00~15:30

　　地点：Grand Ballroom S100bc

　　★　PROMISE (Sex Differences): Sex Differences in Functional Stress Test vs CT Angiography Results and Prognosis in Symptomatic Patients with Suspected Coronary Artery Disease: Insights from the PROMISE Trial

　　●　PROMISE（性别差异）：在疑似冠状动脉疾病的有症状患者中比较功能负荷试验与CT血管造影结果和预后的性别差异

　　★　STOP-CHAGAS: Short and Long Term Effects of Benznidazole， Posaconazole， Monotherapy and their Combination in Eliminating Parasites in Asymptomatic T. cruzi Carriers: The Study of Oral Posaconazole in the Treatment of Asymptomatic Chagas Disease (STOP-CHAGAS Trial)

　　●　STOP-CHAGAS：苄硝唑和泊沙康唑单用及联合治疗消除无症状克氏锥虫携带者寄生虫的短期和长期作用

　　★　STAMPEDE: Bariatric Surgery vs. Intensive Medical Therapy for Long-term Glycemic Control and Complications of Diabetes: Final 5-Year STAMPEDE Trial Results

　　●　STAMPEDE试验最终5年结果：比较减重手术与强化药物治疗用于糖尿病长期血糖控制和并发症治疗

　　★　Vindicate: Vitamin D Supplementation Improves Cardiac Function In Patients With Chronic Heart Failure - Preliminary Results Of The Vitamin D Treating Chronic Heart Failure (vindicate) Study

　　●　Vindicate试验初步结果：维生素D补充剂改善慢性心衰患者的心功能

　　★　RxEACH Trial: The Effect of Community Pharmacist Prescribing and Care on Cardiovascular Risk Reduction: The RxEACH Multicenter Randomized Controlled Trial

　　●　RxEACH试验：社区药师处方和护理对心血管危险下降的影响

　　LBCT深入挖掘专题

　　专题Ⅰ：编号未显示

　　时间：星期日，4月3日，14:00~15:30

　　地点：Grand Ballroom S100bc

　　专题Ⅱ：415

　　时间：星期一，4月4日，12:30~13:45

　　地点：Room S406a

　　●　聆听ACC.16展示的LBCTs亮点，寻找对您及患者的有益信息！